Drugs to Fight Alzheimer's

Although there is no known cure yet for Alzheimer's disease, there are already a number of drugs available worldwide that can help slow down a patient's cognitive deterioration. The main aim of these Alzheimer's medications is to try and improve cognitive ability or the person's capability to think, perceive, judge and recognize. There are currently five drugs approved by the Food and Drug Administration (FDA) that can be used to treat Alzheimer's. There is ongoing research done all the time to test the effectiveness of such medications since they do not serve as a cure-all for the disease. These medications may not have the same effects on all patients that are suffering from Alzheimer's. But such prescription drugs can have significant effects on some of the patients with Alzheimer's disease and should be given consideration as a possible treatment. The 5 FDA Approved Medications are: Aricept Cognex Exelon Razadyne Namenda The first four drugs listed above belong to a group of drugs known as Cholinesterase Inhibitors. They work by trying to delay the break down of a substance known as acetylcholine in the brain which helps in bridging communication between nerve cells and has an important role in a person's memory. Nameda on the other hand acts on another neurotransmitter called glutamate and shields the brain from then said substance which contributes to the death of brain cells in people with Alzheimer's disease. This drug is more effective in treating moderate to severe forms of Alzheimer's disease, improving the day to day life of the person with Alzheimer's disease. The most common side effects associated with the drug Nameda include dizziness, confusion, constipation, headache and skin rashes. Some patients may experience less common side effects such as tiredness, back pain, high blood pressure, insomnia, hallucinations, vomiting and occasional shortness of breath. The drugs Aricept, Exelon and Razadyne are seen to be most effective in treating the early stages of Alzheimer's disease. This group of prescription drugs has been shown to have some modest effect in slowing down the degeneration of a patient's cognitive abilities. These drugs can also help in trying to reduce certain behavioral problems usually exhibited by people suffering from Alzheimer's. When these drugs are administered effectively on an Alzheimer's patient, they can significantly improve one's quality of life and more able to cope up with the disease. Alzheimer's patients taking these medications may experience some side effects which may not be the same for all patients. Common side effects observed in patients using the drug Aricept include nausea, vomiting, excessive tiredness, sleeping troubles and muscle cramps. Less frequent observed side effects of the drug are headaches and dizziness with rare cases of patients suffering from anorexia, gastric or duodenal ulcers, gastro-intestinal hemorrhage, bladder overflow obstruction, liver damage, convulsions, heart problems and psychiatric disturbances while using Aricept as medication. The usual side effects seen in using Exelon as treatment for Alzheimer's are nausea, vomiting, weight loss, stomach upset and fatigue. Less usual side effects observed with the use of the said drug are abdominal pain, sweating, diarrhea, headaches, tremor, and psychiatric disturbances such as anxiety or depression with rare cases of patients experiencing gastro-intestinal bleeding. The drug Cognex is used less frequently for Alzheimer's treatment as it can cause serious liver damage to most patients. Other side effects of the drug include nausea and vomiting. Some patients may also experience some abdominal pain, sore muscles, headache, dizziness, rapid breathing, increased urination, insomnia, runny nose or mouth, swelling in legs and feet when taking Cognex. Some of the most severe side effects associated with using Cornex are liver damage, heart problems and seizures. The common side effects often reported with the use of Razadyne are nausea, vomiting, appetite loss and weight loss. Less common are fatigue, dizziness, tremor, headaches, abdominal pain, urinary tract infection, blood in urine, runny nose. There are no serious side effects with this drug.

Alzheimer's, not just an old man's disease

Alzheimer's disease, we've all hear of it but do we really understand the disease? According to statistics, there are about 350,000 new cases of Alzheimer's disease diagnosed each year in the United States. Doing the math, you could have more than 4.5 million Americans by the year 2050 that would be affected by the disease. A grimmer outlook indicates that by 2025, there will be 34 million people worldwide Alzheimers disease. Let's tackle the issue step by step. Alzheimer's disease is a known brain disorder that is progressive and irreversible. It is still not known where and how the disorder develops in the human brain neither is there any sure fire cure for the disease. What is known by medical scientists is that the disease attacks slowly. It takes its time, gnawing slowly at the victims' minds stealing memories and causing deterioration of brain functions. Alzheimer's is a disease that causes irreversible dementia and is always fatal. It was German psychiatrist Dr. Alois Alzheimer who first identified the disease. At first he noted the disease's symptoms as "amnestic writing disordear," however when later studies were conducted Dr. Alzheimer found out that the symptoms were more than ordinary memory loss. It was far worse. Dr. Alzheimer found the presence of neurofibrillary tangles and amyloid plaques in the brain. The good doctor presented his findings which were accepted by the medical community. And soon enough, by 1910 the name of the disease was accepted and became known as Alzheimer's disease. The most common early symptoms of the disease are confusion, being inattentive and have problems with orientation, personality changes, experiencing short-term memory loss, language difficulties and mood swings. Probably the most obvious and striking early symptom of Alzheimer's is loss of short term memory. At fist the victim will exhibits minor forgetfulness, but as the disease slowly progress he/she will start to forget a lot of things. However, older memories are oftentimes left untouched. Because of this, patients with Alzheimer's will start to be less energetic and spontaneous. As the disease progress, they will have trouble learning new things and reacting on outside stimuli which gets them all confused and causes them to exercise poor judgment. This is considered Stage 1 of the disease. At Stage 2 the patient will now need assistance in performing complicated tasks. Speech and understanding is evidently slower. At this stage, Alzheimer's victims are already aware that they have the disease which causes a whole lot of problems like depression and restlessness. At this point, only the distant past can be recalled and recent events are immediately forgotten. Patients will have difficulty telling time, date and where they are. The final stage is of course the hardest, both for the patient and their family. At Stage 3 the patient will start to lose control of a lot of bodily functions like simple chewing and swallowing. He/she will start getting the needed nutrients through a tube. At Stage 3, the patient will no longer remember basically anyone. They will lose bowel and bladder control and they will become vulnerable to third party infections and diseases like pneumonia. Once the patient become bedridden, things will only get worse. Respiratory problems will become more terrible. It is apparent that the patient will need constant care. At this point, the most one can do is to make sure that the patient stays as comfortable as possible. At the terminal stage, death is inevitable.

Drugs as a Treatment for Alzheimers

As more and more individuals are diagnosed with the debilitating Alzheimers disease, more and more information are coming up as scientists and researchers continue to find out more about this enigmatic type of dementia. Despite this however, a lot of questions remain unanswered. These unanswered questions are hampering experts from finding out the cause of the disease as well as the cure. What is known for a fact is that individuals begin to become susceptible to the disease at the age of 65 and above. It is also known that Alzheimers disease attack the brain and causes an abnormality there, which in turn causes the loss of normal functions in the body. When a person has Alzheimers, he or she will have an abnormal deposit of brain protein that destroys the brain's neurons, nerves and neurotransmitters. An autopsy of the brain of the person who suffered from Alzheimers will show a decrease of brain size and a smoother surface. If experts can absolutely conclude on the causes of Alzheimers then perhaps an Alzheimers drug as a vaccine can be administered to individuals to be able to inhibit the ailment from happening. The statistics on Alzheimers cases are starting to raise much concern because care for individuals with this disease can rake up a lot of money that may in turn put a dent on a country's health care system funds because of the alarming number of cases of individuals with Alzheimers. Intensive care and costs are entailed for individuals who suffer from this because although at the onset and mild stage of the disease, only a slight short term memory loss is perceived, eventually the sufferer will lose more and more cognitive abilities. The person will begin to forget things more and more and will even begin to lose recognition of people and things that are a close part of his or life. There will also be marked instances of uncontrollable changes in behavior. As the disease advances, the Alzheimers sufferer will begin to lose more and more motor skills and the ability to function independently from another. They will then have to be cared for by qualified caregivers who will have to take care of getting them fed and mobile when needed. Aside from this though, the most imperative need for concrete answers in terms of Alzheimers drug treatments lies in the fact that this disease is irreversible and inexorably progresses into death. At present, Alzheimers disease has no known cure and Alzheimers drug treatments give only slight symptomatic relief for some patients but in no way can it buy an individual more time. This claim has been debated however by pharmaceutical companies. For more information about Alzheimers drug treatments: what has been observed to work and what hasn't; check out literature on The American Association for Geriatric Psychiatry's official statement. There is no reason to lose hope however because involved sectors are doing all they can to be able to conquer this disease. As more and more breakthroughs on the subject arise, there is no doubt that perhaps in the near future, an Alzheimers drug will be found successful in treating and curing this disease. In the meantime, friends, loved ones and caregivers of individuals with Alzheimers need to stay abreast of the latest news and breakthroughs in the field of Alzheimers research.

Alzheimer's Disease

People tend to forget certain things because of work and other priorities. This is not uncommon because this does happen to everybody. However, when an individual tends to forget even the simplest things, there is already something definitely wrong. There is a chance that one has Alzheimer's disease. Alzheimer's disease is a disorder in the brain. In time, the patient will gradually lose both the intellectual and social abilities making it difficult to do anything and even interact with others. This disease commonly afflicts people above 65 years of age. There are currently 4.5 million Americans that are suffering from this disease. It is projected that this number will increase, as the more population will reach the retirement age. There is no known cure yet for Alzheimer's disease. The only thing medical science can do for now is simply delay the inevitable for those who have just been diagnosed with the disease. Is Alzheimer's disease the same as dementia? The answer is no. This is because dementia is a symptom, which is caused by a disorder such as Alzheimer's disease. There are many symptoms for this disease. It may begin with the person simply forgetting certain things. It is hard to tell at this point but when it gets worse such as not knowing how to get to the office or get home, then there is definitely a problem. Some patients are known to forget how to do some simple mathematical computations or even find the right words when writing a letter. There are those who are also disoriented and find it difficult to do certain tasks and make simple decisions. The worse of these symptoms is perhaps experiencing personality changes even in the presence of family members and close friends. There are times the person is happy and then this will just change for no reason at all. A neurological scan is the best way to check if the patient has Alzheimer's disease. If it is confirmed, the individual has this problem, the best way to treat it is through the use of medical prescribed drugs. There are two namely memantine and cholinesterase inhibitors. Studies have shown these can slow down the process as scientists are still conducting research to finally find a cure for this disease. Patients who are diagnosed with the disorder will probably live more for 8 more years. This will really depend on how strong the person is because some have lived for 3 while others have fought with it for more than 10 years. How can family members help a loved one with this disease? The siblings can take turns watching over the patient. If this is not possible, this is the time that a caregiver must be hired to check on the patient. This specialist will usually stay in the home and make sure the person is safe. Physical and mental exercises must be administered to keep the patient's strength up and even help depression, which is another symptom commonly, associated with Alzheimer's disease. Whenever the people visit, it is best for each person to stay in the line of sight of the patient. It is best to speak slowly and even hold on to the individual, which is known to make the sufferer remember who he or she is talking to.

Origins unknown, the battle with Alzheimer's continues

One could trace back the history of Alzheimer's disease from a presentation and lecture made by a German psychiatrist in 1906 during 37th Meeting of Southwest German Psychiatrists held in Tbingen. Dr. Alois Alzheimer presented his findings on a woman who had died after years of having memory problems and confusion. When Dr. Alzheimer autopsied the patient's brain, he found thick deposits of neuritic plaques outside and around the nerve cells. He also found a lot of twisted bands of fibers or neurofibrillary tangles inside the nerve cells. Today, medical specialists need to find the presence of the same plaques and tangles at autopsy in order to have a conclusive diagnosis that Alzheimer's disease indeed caused the disease. And due to this lecture and achievement in research and studies, the medical community has bestowed the honor of naming the disease after Dr. Alzheimer. However, Dr. Alzheimer's work only signaled the start of years of medical research and studies which could only resolve the mysteries of the disease by so much. Up until now, Alzheimer's disease has still unknown origin and remains to have no cure. At first, the diagnosis of Alzheimer's disease was limited for individuals between the ages of 45-65 since the symptoms of pre-senile dementia due to the histopathologic process are more common and prominent during this age. However, during the 1970s and early 1980s, the term Alzheimer's disease began to be used to refer to patients of all ages that manifest the same symptoms. Statistics show that around 350,000 new cases of Alzheimer's disease are being diagnosed each year. It is estimated that by 2050, there are 4.5 million Americans afflicted by the disease. Recent studies have shown that there is an increase risk of contracting and developing Alzheimers as one grows older. It has been reported that 5 percent of Americans between the ages of 65 to 74 suffer from Alzheimers disease. Also, half of those in the 85 years and older age group are more likely to have the disease. Generics have also been seen as a factor in the development of the disease. Scientists have found out that mutations on chromosomes 9 and 19 have been associated with the later stages of Alzheimer's. However, not everyone that manifests the mutations results to having the disease. Up until now, the relationship between genetics and late-onset Alzheimer's is still a grey area. Meanwhile, other research have associated trauma as a factor that increases the risk of acquiring the disease. There are also evidences which suggest that lack of exercise increases the risk factor of Alzheimer's. It is important to avoid high blood pressure, high cholesterol, and low levels folate in order to decrease the risk of developing the disease. There are basically three stages of Alzheimer's disease. Stage 1 or Mild Stage is the early of the disease. At this stage patients become less energetic and will experience slight memory loss. Often times, the symptoms at this stage are either go unnoticed or are ignored as but trivial or normal occurrences. At Stage 2 or Moderate stage, the patient needs to be assisted in some complicated tasks and memory loss is no highly noticeable. The final stage is the severest stage. Because the disease already progresses too far this point, the patient is unable to perform simple tasks and will lose the ability to walk or eat without help.

Alzheimers and Dementia

Alzheimers and dementia are strongly linked because Alzheimers disease is the most common type of dementia. Dementia is the constant evolution of the atrophy of the brain's cognitive functions. In the case of Alzheimers, abnormal protein build up happen in the brain which interferes with its normal functions through interactions with the brain nerves and neurotransmitters that cause these elements to whither and die. Alzheimers and dementia are attributed with progressive memory loss and other functions that are attributed to brain deterioration. Natural brain atrophy and cognitive function loss is a normal experience by humans as we age. However, Alzheimers type of dementia is way beyond that of what is considered the norm. Alzheimers type dementia is extremely debilitating and the disease can run its course from as fast as 5 years but some cases stretch on to 20 years. The disruption of Alzheimers type dementia can be very confusing and difficult. What's really hard to accept is that as of the moment, there are no known cures or successful treatments available for Alzheimers patients. Of all the types of dementia, only a very tiny percentage is reversible and Alzheimers is not one of them. Once it attacks, there can be no slowing or stopping down. All one can do is be prepared for the onslaught. In this case, it is also important the patient's friends and loved one understand and know all about Alzheimers and dementia so that they too can be allowed to cope with this situation. If you suffer from the very early stages of Alzheimers type dementia, it can be very difficult for you to accept what is happening to you while you are aware of your situation. Often times, patients can create very difficult situations for themselves as well as for the people around them. For instance, people with Alzheimers type dementia can have the same conversation with the same person over and over again without realizing it. Perhaps a person with Alzheimers type dementia can forget that they have just previously called a loved one to tell them something only to put the phone down and call right back to talk about the exact same thing. Situations like these can cause difficulties that is why it is important for people with Alzheimers type dementia to have the proper care. Loss of correct judgment will inadvertently follow as the Alzheimers type dementia progresses so it might be prudent for patients to be supervised all the time. Eventually, patients will have to depend exclusively on specialized care for all their needs. This makes it important for patients and their loved ones to choose the right facility for this process. It is important that people with Alzheimers type dementia be treated with respect and dignity all throughout the duration of the disease. While the patient has not lost all ability to make judgments and remember important things, they should be consulted in terms of what facilities or type of professional care they think they would benefit from. As a loved one of someone who has Alzheimers type dementia, it can be very hard and painful to witness the progressing of the disease. This may cause some negative emotions and a lot of grief that may be unwittingly projected at the patient. However, at the onset of the disease, when the patient is still conscious and aware, they can go through an even more painful process of accepting their disease.

Alzheimer's Care Facility

More than 4 million Americans are suffering from Alzheimer's disease. Statistics show that the number of sufferers will continue to increase as more people will reach the retirement age. People who are diagnosed with the disorder do not have to be confined in the hospital. The best Alzheimer's care facility does not cost much because the patient can be treated in the comforts of one's home. What are the changes that need to be done to the home? The good news is, none. Those who are taking care of the patient should just be sure it is clean, clutter and noise free at all times. If the family members are busy with other things, an ad can be placed in the paper or someone can call the agency to have a caregiver look after the sufferer. These specialists are trained to give aid to the patient. What activities are done in the care facility? For starters, memory exercises will be done so the patient can still remember the names of the family members. A basic one will be through the use of flash cards that have the name and photo of the person. Most of the time, the caretaker will be beside the patient. Instead of doing nothing, it wouldnt hurt to strike up a conversation. It does not have to be anything serious but just enough to keep the person active because an inactive mind may lead to depression. The individual should always make eye-to-eye contact when talking to the patient at the same time speaking slowly and clearly for the other person to understand. Alzheimer sufferers tend to wander off. The patient could walk to the end of the street or even walk farther without the caretaker even knowing and that is worse. A failsafe system must be put in place such as making sure the doors and windows are locked at all times. Should the patient manage to get out, the second fail-safe will be to attach a bracelet or a card. This will make it easy for someone to return the person home or be informed where the sufferer can be picked up. The Alzheimer's care facility is open 24/7 with most of the concentration spent at night. This is because the symptoms are more active during this time so the best way to calm the patient down is through a little exercise. The patient can help do the dishes or work on the laundry. A cup of warm milk or tea can be given. If this doesn't work, perhaps going for a little stroll together outside for a little exercise may make the sufferer sleepy and go off to bed. Some states have nursing homes and reputable home care facilities to treat the patient. There are numbers in the directory as well as in the Internet that people can inquire. The individual should not be surprised should the place not accept just anyone who can no longer take on the burden of taking care of the loved one because of the limited space and the stage of the disease. The person can choose to pay a huge sum or spend the remaining days with the loved one close to home to at least have a few good memories until the patient will finally go off to a better place.